HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA PDF

The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–base pair ‘core’ sequence similar to the. Genetic analysis is now simplified by the availability of probes for hypervariable regions of human DNA showing multiallelic variation and correspondingly. A minisatellite is a tract of repetitive DNA in which certain DNA motifs are typically repeated times. Minisatellites occur at more than 1, locations in the human genome and In humans, 90% of minisatellites are found at the sub- telomeric region of “Hypervariable ‘minisatellite’ regions in human DNA”. Nature.

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Studies have shown [ citation needed ] that the evolutionary fate of minisatellites tends towards an equilibrium distribution in the size of alleles, until mutations in the flanking DNA affect the recombinational activity of a minisatellite by suppressing DNA instability. Such an event would ultimately lead to the extinction of a hypermutable minisatellite by meiotic drive. When shorter 10—bp tandem repeats were later identified, they came to be known as minisatellites.

You could not be signed in. Email alerts New issue alert. Sequences flanking the repeat arrays of human minlsatellites: Please add a reason or a talk parameter to this template to explain the issue with the article.

Repeat turnover therefore appears to be controlled by recombinational activity in DNA that flanks the repeat array and results in a polarity of mutation. Oxford University Press is a department of the University of Oxford.

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Jeffreys; Sequences flanking the repeat arrays of human minlsatellites: The human telomere sequence itself is a tandem repeat: Minisatellites are prominent in the centromeres and telomeres of chromosomes, the latter protecting the chromosomes from damage. If you originally registered with a username please use that to sign in.

Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes.

Hypervariable ‘minisatellite’ regions in human DNA.

We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function. Abstract We present DNA sequences flanking cloned hypervariable human minisatellites. They are generally non-coding DNA but sometimes are part of possible genes.

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Additional analyses of DNA sequences flanking human minisatellites have also revealed an intense and highly localized meiotic crossover hotspot that is centered upstream of the unstable side of minisatellite arrays.

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing.

Hypervariable ‘minisatellite’ regions in human DNA – Semantic Scholar

Minisatellites were subsequently also used for genetic markers in linkage analysis and population studies, but were soon replaced by microsatellite profiling hyppervariable the s. Citing articles via Web of Science Finally, with the discovery of tandem iterations of simple sequence motifs, the term microsatellites was coined. Emery’s Elements of Medical Genetics, 12th. Don’t have an account? Please help improve it or discuss these issues on the talk page. Somatic instability detected in blood DNA shows simple and rare intra-allelic events two to three orders of magnitude lower rregions in sperm.

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From Wikipedia, the free encyclopedia. This article is about the DNA sequence. WikiProject Genetics may be able to help recruit an hyperariable. Most users should sign in with their email address. July Learn how and when to remove this template message. Hypervariable minisatellites have core units 9—64 bp long and are found mainly at the centromeric regions.

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You do not currently have access to this article. Add comment Close comment form modal. For the size class of orbiting spacecraft, see miniaturized satellite. Minisatellites have been associated with chromosome fragile sites and are proximal to a number of recurrent translocation breakpoints. In contrast, complex inter-allelic conversion-like events occur in the germline. Close mobile search navigation Article navigation.

In alternative models, it is uypervariable presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations. More on this topic A novel tRNA variable number tandem repeat at human chromosome 1q We present DNA sequences flanking cloned hypervariable human minisatellites.

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You have entered an invalid code. Minisatellites are small sequences of DNA that do not encode proteins but appear throughout the genome hundreds of times, with many repeated copies lying next to each other. This article may be confusing or unclear to readers.

Receive exclusive offers and updates from Oxford Academic. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements. Sign In Forgot password? It has been proposed that minisatellite sequences encourage chromosomes to swap DNA.